Cytokine

Statistical data of the results of the manuscript

IL-23 cytokine is induced by TNFalpha, IL-17A, and EGF in keratinocytes

Structural similarity matrix after percentage of structurally aligned residues, S-scores, reported by DaliLite

Structure-guided multiple sequence alignment including mouse and human γc cytokines

Keywords: intercellular adhesion molecule-1; vascular cell adhesion molecule-1; blood pressure variability; 24-hour ambulatory blood pressure monitoring; diabetes mellitus.

Structural similarity matrix obtained after Z-scores reported by DaliLite

Complete tertiary structures of mouse and human gamma common cytokines

Enhancement of the magnitude or affinity of protective antibodies (Abs) induced by vaccine adjuvant is highly desirable to prevent challenging pathogens such as HIV-1. IL-21 plays a crucial role in germinal center reactions during humoral immune responses. However, the effect of IL-21 as a vaccine adjuvant on the quantity and quality of antigen-specific Abs elicited by DNA prime and MVA boost vaccine, a commonly used vaccine strategy, remains unknown. To close this knowledge gap, female adult B6N mice were primed with DNA vaccine twice (days 0, 14, 100 µg, I.M.) and boosted with MVA vaccine (day 28, 2 ×107 pfu, I.M.) with or without IL-21 DNA adjuvant (days 3, 17, 31, 40 µg, I.M.), in which HIV-1 gag was expressed as a model antigen. With the addition of IL-21 adjuvant, we found significantly increased avidity of antigen-specific Abs at multiple time points in longitudinal follow up. Collectively, our results suggest that IL-21 immune adjuvant can significantly increase Ab quality induced by heterologous DNA-MVA prime-boost vaccine strategy.

Detailed data tables of the paper: Tunicamycin-induced endoplasmic reticulum stress up-regulates tumour-promoting cytokines in oral squamous cell carcinoma.

Attached data were cytokine analysis of BALF in Sarcoidosis and IgG-4RRD.