Journal of Functional Foods

These data include the original data of this experiment, including the inhibition rate of probiotics on cell proliferation, apoptosis rate, inflammatory factor level and data of transcriptomics.

An explanation of the data in the article.

The dataset includes all statistical analysis files for the paper "Lucyoside B, a triterpenoid saponin from Luffa cylindrica, inhibits the production of inflammatory mediators via both nuclear factor-κB and activator protein-1 pathways in activated macrophages". There is curently 21 files avaliable.The type of all files is GraphPad Prism 7 XML Project (.pzfx). The data were analyzed using GraphPad Prism Version 7.0. A Student’s t-test was used when only two groups were compared. When there were more than two groups, the intergroup significance was analyzed using one-way ANOVA with Tukey post hoc analysis. Differences were considered to be significant at P < 0.05.

In this study, we aimed to determine the therapeutic potential of crude polysaccharide (DIP) that was isolated from the mushroom Dictyophora indusiata in the amelioration of DSS induced colitis. Previously, our research group has reported DIP activity in the restoration of gut microbiota in an antibiotic driven intestinal dysbiosis mouse model. Kanwal, S., Joseph, T., Owusu, L., Xiaomeng, R., Meiqi, L., & Yi, X. (2018). A polysaccharide isolated from Dictyophora indusiata promotes recovery from antibiotic-driven intestinal dysbiosis and improves gut epithelial barrier function in a mouse model. Nutrients, 10(8), 1003. So far numerous biological activities of polysaccharide from the mushroom D.indusiata have been reported, however, to the best of our knowledge, its impact on the DSS induced colitis has not been explored yet. In this study, we investigated the role and contribution of DIP in the attenuation of DSS induced colitis. Our finding revealed a promising effect of DIP in the alleviation of DSS induced colitis and associated symptoms. We believe, that this study will add value in the implication of polysaccharide DIP from the mushroom D.indusiata as dietary therapeutics after detailed pre-clinical and clinical studies.

raw data