Translational Oncology

Nanostring data from pancancer panel analysis of LNCaP cells treated with AS602801, Enzalutamide, or both.

ddPCR raw data files

a b s t r a c tStudies have shown that 9.4 Tesla (9.4 T) high-field magnetic resonance imaging (MRI) has obvious advantages inimproving image resolution and capacity, but their safety issues need to be further validated before their clinicalapproval. Meanwhile, emerging experimental evidences show that moderate to high intensity Static MagneticFields (SMFs) have some anti-cancer effects.We examined the effects of two opposite SMF directions on lung cancer bearing mice and found when the lungcancer cell-bearing mice were treated with 9.4 T SMFs for 88 h in total, the upward 9.4 T SMF significantlyinhibited A549 tumor growth (tumor growth inhibition=41%), but not the downward 9.4 T SMF. In vitro cellularanalysis shows that 9.4 T upward SMF treatment for 24 h not only inhibited A549 DNA synthesis, but alsosignificantly increased ROS and P53 levels, and arrested G2 cell cycle. Moreover, the 9.4 T SMF-treatments for88 h had no severe impairment to the key organs or blood cell count of the mice.Our findings demonstrated the safety of 9.4 T SMF long-term exposure for their future applications in MRI, andrevealed the anti-cancer potential of the upward direction 9.4 T SMF.