Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

According to the time of onset, the severe PE patients were further divided into early onset (diagnosis of PE at < 34 weeks) PE subgroup (n = 38) and late onset (diagnosis of PE at ≥ 34 weeks) PE subgroup (n = 44). Maternal serum CypA levels were dectected in 48 severe PE patients (22 early onset PE and 26 late onset PE) and 40 healthy pregnancies by age matching method from the samples for genotyping. 40 placenta tissues from 20 severe PE patients (11 early onset PE and 9 late onset PE) and 20 age matched healthy controls were chosed for mRNA and protein detection. Clinical characteristics of these subgroups were analyzed in the supplementary tables.

Raw data of the study participants

Raw data of the study.

Methods: We conducted a prospective case control study in 50 pregnant women admitted to King George Hospital (under Andhra Medical college) Visakhapatnam India from 2012 to 2014, with gestational hypertension and preeclampsia, recruited as cases by simple random sampling. In diagnosing these hypertensive disorders NHBPEP working Group classification with modifications recommended by ACOG Task Force on Hypertension in Pregnancy was followed (6).50 normotensive pregnant women were recruited as control group and age and gestation-matched groups. All these women were in 3rd trimester of pregnancy. All women with hypertension were on antihypertensive treatment with oral labetalol or nifedipine. Women with severe hypertension were treated with either oral nifedipine and parenteral labetalol or combination. We excluded antenatal women with medical comorbidities such as chronic hypertension, heart disease, diabetes mellitus, renal disease, moderate or severe anemia and multiple pregnancy. On admission, cases and controls were assessed clinically, by appropriate laboratory work up and ultrasonography for fetal assessment. Definitions: 1. Gestational Hypertension: New onset hypertension with BP≥140/90 after 20weeks of gestation without proteinuria or end organ dysfunction 2. Preeclampsia: New onset hypertension with BP≥140/90 after 20weeks of gestation with proteinuria or end organ dysfunction 3. Severe preeclampsia /Preeclampsia with severe features as defined by ACOG Taskforce 2013.

Home blood pressure and clinic blood pressure in pregnancy