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The American Journal of Pathology

ISSN: 0002-9440

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Datasets associated with articles published in The American Journal of Pathology

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1970
2024
1970 2024
7 results
  • Data for: Chd7 is critical for early T-cell development and thymus organogenesis
    Liu, Zhi-Zhi, Xu, Hong, Huang, Wen-Ting, Choi, Taeik, Zhu, Lou-Yin et al
    Published 30 August 2018 | Mendeley Data
    Authors’ manuscript of “Chd7 is critical for early T-cell development and thymus organogenesis”
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  • Solution structure of the Orange domain from human protein HES1
    Fan, J.S., Nayak, A., Swaminathan, K.
    Published 18 May 2020 | Protein Data Bank
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  • Dataset related to article "Antitumor Activity of a Novel Fibroblast Growth Factor Receptor Inhibitor for Intrahepatic Cholangiocarcinoma."
    Raggi C, Fiaccadori K, Pastore M, Correnti M, Piombanti B et al
    Published 17 March 2020 | Zenodo
    Fibroblast growth factor receptor 2 (FGFR2) might have an important role in the pathogenesis and biology of cholangiocarcinoma (CCA). We examined FGFR expression in CCA tumor specimens obtained from patients and CCA cell lines, and then determined the effects of the novel FGFR inhibitor, derazantinib (DZB; formally, ARQ 087), which is currently in clinical phase 2 trials for intrahepatic CCA. DZB inhibited the growth of CCA cell lines in a dose-dependent manner, and extracellular signal-regulated kinase 1/2 and AKT. It also activated apoptotic and cell growth arrest signaling. DZB reduced the in vitro invasiveness and the expression of key epithelial-mesenchymal transition genes. The in vitro data correlated with the expression of FGFRs in human CCA specimens by immunohistochemistry (FGFR1, 30% positive; and FGFR2, 65% positive) and the CCA cell lines assayed by Western blot analysis. These correlated in vitro studies suggest that FGFR may play an important role in the pathogenesis and biology of CCA. Our findings support the notion that FGFR inhibitors, like DZB, should be further evaluated at the clinical stage as targeted therapy for CCA treatment.
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  • Microscopy product ID: 9525. In Cell Centered Database
    Van Den Berg, Bernard M., Rabelink, Ton J., Dane, Martijn J. C., Avramut, M. Cristina, Faas, Frank G. A. et al
    Published 1 January 2017 | UC San Diego
    Male. Strain: C57BL/6
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  • Microscopy product ID: 9523. In Cell Centered Database
    Van Den Berg, Bernard M., Rabelink, Ton J., Dane, Martijn J. C., Avramut, M. Cristina, Faas, Frank G. A. et al
    Published 1 January 2017 | UC San Diego
    Male. Strain: C57BL/6
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  • Microscopy product ID: 9524. In Cell Centered Database
    Van Den Berg, Bernard M., Rabelink, Ton J., Dane, Martijn J. C., Avramut, M. Cristina, Faas, Frank G. A. et al
    Published 1 January 2017 | UC San Diego
    Product type: MOSAIC. Microscopy type: TRANSMITTED LIGHT. Instrument: Leitz Orthoplan microscope equipped for epi-illumination, and adapted for reflection contrast microscopy
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  • Microscopy product ID: 9526. In Cell Centered Database
    Van Den Berg, Bernard M., Rabelink, Ton J., Dane, Martijn J. C., Avramut, M. Cristina, Faas, Frank G. A. et al
    Published 1 January 2017 | UC San Diego
    Product type: MOSAIC. Microscopy type: TRANSMITTED LIGHT. Instrument: Leitz Orthoplan microscope equipped for epi-illumination, and adapted for reflection contrast microscopy
    • Dataset
    Export:APABibTeXDataCiteRIS