Journal of the Neurological Sciences

Raw data of the new methods.

This raw data was used statistically in this paper.

The excel sheets containing demographic and genetic data.

In the first sheet, we show raw data about demographical data, Mini-Mental State Examination, Unified Parkinson's disease rating scale, Hoehn & Yahr score, International prostatic symptoms (IPSS) and Nocturia Quality of Life (NQoL) scores. In the second sheet, we show non parametric Wilcoxon's test analysis used to compare IPSS score at baseline and at the end of treatment period and Spearman's correlation analysis between IPSS (global and specifically for item 7) with disease duration and UPDRS (part III). The third sheet shows Spearman's correlation analysis between delta NQoL score with disease duration and UPDRS (part III). Our data show significant improvement on both IPSS and NQoL scores following 2 months of Extended Release of Levodopa treatment.

The MasterSheet.csv file contains all outcome measures described in this submission. The LongitudinalAnalysis.sas file contains the code used to analyze this data.

Data of the VPD study in the research is included in this data set.

Excel spreadsheet with value of optic nerve sheath diameter, parameters of transcranial Doppler ultrasonography of the middle cerebral artery and internal carotid artery, blood pressure and heart rate for pre-inversion, 3-minute inversion and post-inversion.

dataset relateto to article at title

The dataset contains the variables used to validata the PLIHS scale described in the manuscript.

This record contains raw data related to article “Impulse control behavior in GBA-mutated parkinsonian patients" Objective: To assess the prevalence and phenomenology of Impulse control behavior (ICB) in Parkinson's disease (PD) patients carrying mutations in the β-glucocerebrosidase (GBA) gene. Background: GBA mutations are a common genetic factor predisposing to PD. ICB is among the most disabling non-motor complications of PD. The occurrence of ICB in PD patients carrying GBA gene mutations (GBA-PD) has not been yet established. Methods: Forty-six patients with clinically definite PD (23 GBA-PD and 23 non-mutated patients, NM-PD) were screened for ICB. Diagnosis was clinically and rating based on a specific questionnaire (QUIP-RS). Other demographic and clinical variables did not differ between groups. Results: ICB occurred more frequently in GBA-PD patients (52.2%) compared to NM-PD (13%) and the total QUIP-RS score was higher in the GBA-PD group. Hypersexuality and compulsive shopping were the most prevalent ICB types occurring in GBA patients. ICB occurred only in one GBA-PD patient on levodopa monotherapy and in 11 patients taking dopamine agonists, either monotherapy or combined with levodopa (the corresponding figures in NM-PD patients were 0 and 3). Most GBA-PD patients were heterozygous for two common genetic variants, without appreciable difference in their ICB profile. Conclusion: ICB is more common in GBA-PD patients compared to NM-PD. Dopamine agonist therapy may be synergic to GBA carrier status for ICB occurrence.