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- Data for: Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cellsThis dataset includes the cytokine secretion data as concentrations measured from each cell culture supernatant. The data corresponds to Figures 4 and 5 and Table 1 in the manuscript, in which the data is presented as secretion indices calculated from the cytokine concentrations.
- Dataset
- Data for: Hydrogen peroxide modulates clock gene expression via RORa and REV-ERBα/βOriginal figures of the representative images in the manuscript.
- Dataset
- Data for: Vitamin D protects against oxidative stress, inflammation and hepatorenal damage induced by acute paracetamol toxicity in rat.Vitamin D protects against oxidative stress, inflammation and hepatorenal damage induced by acute paracetamol toxicity in rat.
- Dataset
- Data for: Upper ocean oxygenation, evolution of Rubisco and the Phanerozoic succession of Phytoplankton; compilation of biochemical properties of RubiscoCompilation of Specificity, affinity for carbon dioxide (Kc), affinity for oxygen (Ko), turnover rate of carbon dioxide (kcatc), turnover rate of oxygen (kcato) for a range of organisms hosting Form I and Form II Rubiscos with references for original data
- Dataset
- Data for: Upper ocean oxygenation, evolution of Rubisco and the Phanerozoic succession of PhytoplanktonCompilation of biochemical kinetic data from Ribulose‐1,5‐bisphosphate carboxylase/ oxygenase (RuBisCO, EC 4.1.1.39)
- Dataset
- Data for: Endothelial cell glucose metabolism is modulated by the flavonoid quercetin through actions on HIF1a signaling and energy regulating genesData showing changes in HUVECs after treatment with quercetin or DMOG and assessment of gene expression, glucose uptake and protein expression.
- Dataset
- Crystal Structure of Medicago truncatula Nodulin 13 (MtN13) in complex with 3-carboxybenzophenone
- Dataset
- Dataset related to the article "Pro-oxidant and pro-inflammatory effects of glycated albumin on cardiomyocytes"This record contains raw data related to the article "Pro-oxidant and pro-inflammatory effects of glycated albumin on cardiomyocytes" A B S T R A C T Human serum albumin (HSA) is the most abundant circulating protein in the body and presents an extensive range of biological functions. As such, it is prone to undergo post-translational modifications (PTMs). The nonenzymatic early glycation of HSA, one of the several PTMs undergone by HSA, arises from the addition of reducing sugars to amine group residues, thus modifying the structure of HSA. These changes may affect HSA functions impairing its biological activity, finally leading to cell damage. The aim of this study was to quantitate glycated-HSA (GA) levels in the plasma of heart failure (HF) patients and to evaluate the biological effects of GA on HL-1 cardiomyocytes. Plasma GA content from HF patients and healthy subjects was measured by direct infusion electrospray ionization mass spectrometry (ESI-MS). Results pointed out a significant increase of GA in HF patients with respect to the control group (p < 0.05). Additionally, after stimulation with GA, proteomic analysis of HL-1 secreted proteins showed the modulation of several proteins involved, among other processes, in the response to stress. Further, stimulated cells showed a rapid increase in ROS generation, higher mRNA levels of the inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), and higher levels of the oxidative 4-HNE-protein adducts and carbonylated proteins. Our findings show that plasma GA is increased in HF patients. Further, GA exerts pro-inflammatory and prooxidant effects on cardiomyocytes, which suggest a causal role in the etiopathogenesis of HF.
- Dataset
- Yeast Thiol Specific antoxidant 2 with C171S mutation and catalytic cysteine alkylated with iodoacetamide
- Dataset
- Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 1-[(dimethylamino)methyl]-2-naphthol at 1 hour of soaking
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